Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms
نویسندگان
چکیده
منابع مشابه
Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms.
Synapse loss occurs normally during development and pathologically during neurodegenerative disease. Long-term depression, a proposed physiological correlate of synapse elimination, requires caspase-3 and the mitochondrial pathway of apoptosis. Here, we show that caspase-3 activity is essential--and can act locally within neurons--for regulation of spine density and dendrite morphology. By phot...
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Spine Ca 2 triggers the induction of synaptic plasticity and other adaptive neuronal responses. The amplitude and time course of Ca 2 signals specify the activation of the signaling pathways that trigger different forms of plasticity such as long-term potentiation and depression. The shapes of Ca 2 signals are determined by the dynamics of Ca 2 sources, Ca 2 buffers, and Ca 2 extrusion mechanis...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2014
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3121-13.2014